Overview
SCIENTIFIC SCORE
Questionable
Based on 7 Researches
6.6
USERS' SCORE
Good
Based on 2 Reviews
8.5
Supplement Facts
Serving Size: 2 Tablets
Amount Per Serving
%DV
Vitamin D3 (as Cholecalciferol)
13 mcg (500 IU)
63%
Calcium (as Calcium Citrate)
630 mg
48%
Top Medical Research Studies
8
Vitamin D improves heart disease factors
We conducted a double-blind, randomized clinical trial to see how treating vitamin D deficiency could influence heart health, particularly in patients with ischemic heart disease (IHD). In our study, 44 IHD patients aged 40 to 65 were treated with either vitamin D or a placebo to assess changes in their lipid profiles and C-reactive protein (CRP) levels.
Our findings revealed that participants who received vitamin D supplementation showed notable improvements. Specifically, we observed higher levels of high-density lipoprotein cholesterol (HDL-C)—often referred to as the "good" cholesterol—and lower triglyceride levels among those treated with vitamin D. Interestingly, the increase in HDL-C and improvement in triglyceride levels underscore vitamin D’s potential role in enhancing lipid profiles in patients struggling with heart disease.
We also noted that vitamin D treatment didn’t significantly impact CRP levels, which are typically used as a marker for inflammation and heart disease risk. This suggests that while vitamin D might help improve certain lipids, its effects on other markers of heart disease need further investigation.
Overall, our study highlights the potential benefits of vitamin D supplementation as a tool to manage heart disease risk factors, offering a promising option for healthcare professionals working with patients suffering from IHD.
Our findings revealed that participants who received vitamin D supplementation showed notable improvements. Specifically, we observed higher levels of high-density lipoprotein cholesterol (HDL-C)—often referred to as the "good" cholesterol—and lower triglyceride levels among those treated with vitamin D. Interestingly, the increase in HDL-C and improvement in triglyceride levels underscore vitamin D’s potential role in enhancing lipid profiles in patients struggling with heart disease.
We also noted that vitamin D treatment didn’t significantly impact CRP levels, which are typically used as a marker for inflammation and heart disease risk. This suggests that while vitamin D might help improve certain lipids, its effects on other markers of heart disease need further investigation.
Overall, our study highlights the potential benefits of vitamin D supplementation as a tool to manage heart disease risk factors, offering a promising option for healthcare professionals working with patients suffering from IHD.
Read More
7
We explored the effects of vitamin D3 (VitD) on heart cells, focusing on its ability to counteract changes induced by angiotensin II (Ang II), a compound that can contribute to heart disease. The study involved exposing H9c2 cardiomyoblasts—heart muscle cells—to Ang II alone, and then to both Ang II and VitD to see how VitD might help.
Our findings revealed that while VitD effectively reduced the size of the cells and helped lower markers of hypertrophy (a condition where heart cells enlarge often due to strain), it did not significantly improve cell survival in the absence of a protein called sirtuin-1 (SIRT1). When SIRT1 was inhibited, VitD was unable to protect the cells as it normally would. This suggests that SIRT1 is crucial for the pro-survival benefits of vitamin D.
Importantly, while VitD showed promise in tackling hypertrophy, its protective effects rely heavily on SIRT1 being present. This could lead to new ideas for therapies in heart disease, where activating SIRT1 might enhance the benefits of vitamin D to improve heart health.
Our findings revealed that while VitD effectively reduced the size of the cells and helped lower markers of hypertrophy (a condition where heart cells enlarge often due to strain), it did not significantly improve cell survival in the absence of a protein called sirtuin-1 (SIRT1). When SIRT1 was inhibited, VitD was unable to protect the cells as it normally would. This suggests that SIRT1 is crucial for the pro-survival benefits of vitamin D.
Importantly, while VitD showed promise in tackling hypertrophy, its protective effects rely heavily on SIRT1 being present. This could lead to new ideas for therapies in heart disease, where activating SIRT1 might enhance the benefits of vitamin D to improve heart health.
Read More
7
Calcium's limited impact on hypertension
We sought to understand how calcium affects hypertension and cardiovascular disease risk. Through a thorough review of existing literature, we evaluated data from a significant number of studies, focusing on the effects of calcium, magnesium, and vitamin D supplements on blood pressure levels and pulse rates.
Our analysis revealed that while calcium supplementation was linked to a noteworthy drop in diastolic blood pressure (the bottom number in blood pressure readings), it did not show a significant impact on systolic blood pressure (the top number) or pulse rate. This indicates that calcium could play a role in managing the lower blood pressure readings but may not be entirely effective on its own regarding overall blood pressure control.
Additionally, we identified that magnesium also contributed positively by reducing diastolic blood pressure, whereas vitamin D exhibited a broader beneficial effect by lowering both systolic and diastolic blood pressure. Despite these encouraging results for magnesium and vitamin D, calcium’s isolated effectiveness in addressing hypertension remains limited.
Overall, while calcium may help with certain aspects of blood pressure management, its role in controlling hypertension is not as clear-cut as we might hope.
Our analysis revealed that while calcium supplementation was linked to a noteworthy drop in diastolic blood pressure (the bottom number in blood pressure readings), it did not show a significant impact on systolic blood pressure (the top number) or pulse rate. This indicates that calcium could play a role in managing the lower blood pressure readings but may not be entirely effective on its own regarding overall blood pressure control.
Additionally, we identified that magnesium also contributed positively by reducing diastolic blood pressure, whereas vitamin D exhibited a broader beneficial effect by lowering both systolic and diastolic blood pressure. Despite these encouraging results for magnesium and vitamin D, calcium’s isolated effectiveness in addressing hypertension remains limited.
Overall, while calcium may help with certain aspects of blood pressure management, its role in controlling hypertension is not as clear-cut as we might hope.
Read More
Most Useful Reviews
8
Calcium benefits
Good calcium in the form of citrate doesn't cause kidney deposits. I've never had a fracture. I need to order vitamin K2 in the natural menaquinone-7 (MK-7) form. Vitamin K2 helps direct calcium to bones; without it, calcium may calcify blood vessels, which is dangerous for cardiovascular disease.
Read More
9
Improved symptoms
Calcium has become essential for me. This calcium citrate works after 10 days. I take six tablets daily as prescribed, along with alfacalcidol, which boosts calcium absorption. The quality is good at a reasonable price. Considering my postoperative conditions, I find nerve conduction has improved, and symptoms associated with cardiovascular disease have lessened.
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 7 Researches
6.6
- All Researches
8
Vitamin D improves heart disease factors
We conducted a double-blind, randomized clinical trial to see how treating vitamin D deficiency could influence heart health, particularly in patients with ischemic heart disease (IHD). In our study, 44 IHD patients aged 40 to 65 were treated with either vitamin D or a placebo to assess changes in their lipid profiles and C-reactive protein (CRP) levels.
Our findings revealed that participants who received vitamin D supplementation showed notable improvements. Specifically, we observed higher levels of high-density lipoprotein cholesterol (HDL-C)—often referred to as the "good" cholesterol—and lower triglyceride levels among those treated with vitamin D. Interestingly, the increase in HDL-C and improvement in triglyceride levels underscore vitamin D’s potential role in enhancing lipid profiles in patients struggling with heart disease.
We also noted that vitamin D treatment didn’t significantly impact CRP levels, which are typically used as a marker for inflammation and heart disease risk. This suggests that while vitamin D might help improve certain lipids, its effects on other markers of heart disease need further investigation.
Overall, our study highlights the potential benefits of vitamin D supplementation as a tool to manage heart disease risk factors, offering a promising option for healthcare professionals working with patients suffering from IHD.
Our findings revealed that participants who received vitamin D supplementation showed notable improvements. Specifically, we observed higher levels of high-density lipoprotein cholesterol (HDL-C)—often referred to as the "good" cholesterol—and lower triglyceride levels among those treated with vitamin D. Interestingly, the increase in HDL-C and improvement in triglyceride levels underscore vitamin D’s potential role in enhancing lipid profiles in patients struggling with heart disease.
We also noted that vitamin D treatment didn’t significantly impact CRP levels, which are typically used as a marker for inflammation and heart disease risk. This suggests that while vitamin D might help improve certain lipids, its effects on other markers of heart disease need further investigation.
Overall, our study highlights the potential benefits of vitamin D supplementation as a tool to manage heart disease risk factors, offering a promising option for healthcare professionals working with patients suffering from IHD.
Read More
7
We explored how different vitamin D treatments may influence cardiovascular disease (CVD) risk among patients with chronic kidney disease (CKD). Our observational study included 83 CKD patients who were treated with vitamin D or its analogs and had varying histories of CVD. By measuring the thickness of perirenal adipose tissue (PAT) and assessing clinical parameters, we aimed to uncover any links between vitamin D treatment and cardiovascular health.
We found that patients with a history of CVD showed thicker PAT compared to those without such a history. Interestingly, our comparisons among patients receiving different forms of vitamin D revealed that those treated with paricalcitol had less PAT accumulation than those on cholecalciferol or calcitriol. This suggests that the type of vitamin D treatment may play a role in managing CVD risk in CKD patients.
Although our findings indicate differences in PAT thickness related to vitamin D treatment, we did not conduct a controlled trial that would allow us to claim a definitive benefit of vitamin D3 alone on cardiovascular health. It appears that further investigation is necessary to clarify these relationships and understand the mechanisms at play.
We found that patients with a history of CVD showed thicker PAT compared to those without such a history. Interestingly, our comparisons among patients receiving different forms of vitamin D revealed that those treated with paricalcitol had less PAT accumulation than those on cholecalciferol or calcitriol. This suggests that the type of vitamin D treatment may play a role in managing CVD risk in CKD patients.
Although our findings indicate differences in PAT thickness related to vitamin D treatment, we did not conduct a controlled trial that would allow us to claim a definitive benefit of vitamin D3 alone on cardiovascular health. It appears that further investigation is necessary to clarify these relationships and understand the mechanisms at play.
Read More
7
We explored the effects of vitamin D3 (VitD) on heart cells, focusing on its ability to counteract changes induced by angiotensin II (Ang II), a compound that can contribute to heart disease. The study involved exposing H9c2 cardiomyoblasts—heart muscle cells—to Ang II alone, and then to both Ang II and VitD to see how VitD might help.
Our findings revealed that while VitD effectively reduced the size of the cells and helped lower markers of hypertrophy (a condition where heart cells enlarge often due to strain), it did not significantly improve cell survival in the absence of a protein called sirtuin-1 (SIRT1). When SIRT1 was inhibited, VitD was unable to protect the cells as it normally would. This suggests that SIRT1 is crucial for the pro-survival benefits of vitamin D.
Importantly, while VitD showed promise in tackling hypertrophy, its protective effects rely heavily on SIRT1 being present. This could lead to new ideas for therapies in heart disease, where activating SIRT1 might enhance the benefits of vitamin D to improve heart health.
Our findings revealed that while VitD effectively reduced the size of the cells and helped lower markers of hypertrophy (a condition where heart cells enlarge often due to strain), it did not significantly improve cell survival in the absence of a protein called sirtuin-1 (SIRT1). When SIRT1 was inhibited, VitD was unable to protect the cells as it normally would. This suggests that SIRT1 is crucial for the pro-survival benefits of vitamin D.
Importantly, while VitD showed promise in tackling hypertrophy, its protective effects rely heavily on SIRT1 being present. This could lead to new ideas for therapies in heart disease, where activating SIRT1 might enhance the benefits of vitamin D to improve heart health.
Read More
7
In exploring how vitamin D3 influences cardiovascular disease, we conducted experiments with both young and aged mice, who were treated with vitamin D3 or saline to assess its impact on vascular calcification. Out of our findings, it was crucial to note that while vitamin D3 treatments were utilized, we also incorporated Elabela and other compounds, making it challenging to isolate vitamin D3's specific effects on cardiovascular health fully.
Through our study, we observed the potential protective role of Elabela against vascular calcification, particularly acting through pathways that involve PPAR-γ and FDX1 signaling. However, the combination of treatments lacks clarity on the specific benefits of vitamin D3 by itself in managing vascular health. Thus, the data does not present a clear advantage for vitamin D3 in reducing cardiovascular disease risks when considered independently from Elabela.
Overall, our research underlines the complexity of vitamin D3's role in cardiovascular conditions and indicates that more targeted studies are necessary to define its specific contributions clearly.
Through our study, we observed the potential protective role of Elabela against vascular calcification, particularly acting through pathways that involve PPAR-γ and FDX1 signaling. However, the combination of treatments lacks clarity on the specific benefits of vitamin D3 by itself in managing vascular health. Thus, the data does not present a clear advantage for vitamin D3 in reducing cardiovascular disease risks when considered independently from Elabela.
Overall, our research underlines the complexity of vitamin D3's role in cardiovascular conditions and indicates that more targeted studies are necessary to define its specific contributions clearly.
Read More
7
We explored how serum levels of vitamin D3, specifically 25(OH)D, might influence various indicators related to cardiovascular health. Using data from the National Health and Nutrition Examination Survey (NHANES) spanning 2015 to 2018, we analyzed results from 4,727 adults aged 20 and above.
Our investigation focused on several key factors such as body mass index, high-density lipoprotein cholesterol, systolic blood pressure, and cholesterol levels. The results showed that even a slight increase in vitamin D3 levels was associated with positive changes across these cardiovascular risk factors. For instance, we found that a 1 nmol/L increase in serum 25(OH)D led to small but significant improvements in several indicators.
Notably, the effects varied by gender and age, with women showing greater sensitivity to vitamin D3 levels compared to men, while older adults were less responsive. However, our findings highlighted a complex relationship, revealing nonlinear patterns that suggest additional research is necessary to fully understand these dynamics. While the results display promising associations, they do not confirm that vitamin D3 treatment can directly improve cardiovascular disease outcomes.
Our investigation focused on several key factors such as body mass index, high-density lipoprotein cholesterol, systolic blood pressure, and cholesterol levels. The results showed that even a slight increase in vitamin D3 levels was associated with positive changes across these cardiovascular risk factors. For instance, we found that a 1 nmol/L increase in serum 25(OH)D led to small but significant improvements in several indicators.
Notably, the effects varied by gender and age, with women showing greater sensitivity to vitamin D3 levels compared to men, while older adults were less responsive. However, our findings highlighted a complex relationship, revealing nonlinear patterns that suggest additional research is necessary to fully understand these dynamics. While the results display promising associations, they do not confirm that vitamin D3 treatment can directly improve cardiovascular disease outcomes.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
8
Calcium benefits
Good calcium in the form of citrate doesn't cause kidney deposits. I've never had a fracture. I need to order vitamin K2 in the natural menaquinone-7 (MK-7) form. Vitamin K2 helps direct calcium to bones; without it, calcium may calcify blood vessels, which is dangerous for cardiovascular disease.
Read More
9
Improved symptoms
Calcium has become essential for me. This calcium citrate works after 10 days. I take six tablets daily as prescribed, along with alfacalcidol, which boosts calcium absorption. The quality is good at a reasonable price. Considering my postoperative conditions, I find nerve conduction has improved, and symptoms associated with cardiovascular disease have lessened.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Checa-Ros A, Locascio A, Okojie OJ, Abellán-Galiana P, D'Marco L. Perirenal fat differs in patients with chronic kidney disease receiving different vitamin D-based treatments: a preliminary study. BMC Nephrol. 2025;26:119. doi:10.1186/s12882-025-04041-2
- Astani A, Maroofi A, Hekmatimoghaddam S, Sarebanhassanabadi M, Safari F. Sirtuin 1 mediates the pro-survival effects of vitamin D in angiotensin II-induced hypertrophy of H9c2 cardiomyoblasts. Mol Biol Rep. 2024;52:96. doi:10.1007/s11033-024-10168-6
- Qi RQ, Chen YF, Cheng J, Song JW, Chen YH, et al. Elabela alleviates cuproptosis and vascular calcification in vitaminD3- overloaded mice via regulation of the PPAR-γ /FDX1 signaling. Mol Med. 2024;30:223. doi:10.1186/s10020-024-00997-3
- France-Ratcliffe M, Harrison SL, Verma LA, Abdul-Rahim AH, McCallum L, et al. Vitamin D and cardiovascular outcomes in multiple sclerosis. Mult Scler Relat Disord. 2024;92:106155. doi:10.1016/j.msard.2024.106155
- Sadeghi M, Momeni A, Mirsaeidi FS, Jamalian M, Amirpour A, et al. The Effect of Vitamin D Deficiency Treatment on Lipid Profile and C-reactive Protein in Patients with Ischemic Heart Disease: Double-blind Randomized Clinical Trial. Adv Biomed Res. 2024;13:79. doi:10.4103/abr.abr_380_23
- Pan YX, Fu YC, Chen H, Zhao MY. [Association of serum 25(OH)D with cardiovascular risk-related indicators: cross-sectional analysis of NHANES]. Zhonghua Yu Fang Yi Xue Za Zhi. 2024;58:1388. doi:10.3760/cma.j.cn112150-20240519-00403
- Amer SA, Abo-Elnour DE, Abbas A, Abdelrahman AS, Hamdy HM, et al. Calcium, magnesium, and vitamin D supplementations as complementary therapy for hypertensive patients: a systematic review and meta-analysis. BMC Complement Med Ther. 2025;25:89. doi:10.1186/s12906-025-04809-x
